Imad Haddad, MD

Publications and Presentations

Outline

Original Articles

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  1. Alexander D, M Assaf, IY Haddad, and A Barakat. Fructose 1-6 diphosphatase deficiency: Diagnosis using leucocyte and detection of heterozygote with radiochemical and spectrophotometric methods. J Inherit Metab Dis, 8 (4): 174-177, 1985.
  2. Haddad IY, JS Beckman, RI Garver, and S Matalon. Structural and functional alterations of surfactant protein A by peroxynitrite. Chest. 105(3 Suppl):84S, 1994.
  3. Haddad IY, H Ischropoulos, BA Holm, JS Beckman, JR Baker, and S Matalon. Mechanisms of peroxynitrite induced injury to pulmonary surfactant. Am J Physiol 265 (Lung Cell Mol Physiol 9) L555-L564, 1993.
  4. Haddad IY, BA Holm, L Halavaty, and S Matalon, Dependence of surfactant function on extracellular pH: mechanisms and modifications. J Appl Physiol 76 (2): 657-662, 1994.
  5. Haddad IY, J Crow, Y Yoazu, J Beckman and S Matalon. Concurrent generation of nitric oxide and superoxide damages surfactant protein A (AP-A). Am J Physiol 267 (Lung Cell Mol Physiol 11): L242-L249, 1994.
  6. Haddad IY, G Pataki, P Hu, CA Galliani, JS Beckman, and S Matalon. Quantitation of nitrotyrosine levels in the lungs of patients and animals with acute lung injury. J Clin Invest 94: 2407-2413, 1994.
  7. Haddad IY, S Zhu, H Ischiroupolos, and S Matalon. Nitration of Surfactant protein A(SP-A) results in decreased ability to aggregate lipids. Am J Physiol 270 (Lung Cell Mol Physiol 14): L281-L288, 1996.
  8. Haddad IY, S Zhu, J Crow, E Barefield, Thomas Gadilhe, and Sadis Matalon. Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide. Am J Physiol 270 (Lung Cell Mol Physiol 14): L898-L906, 1996.
  9. Matalon S, V Demarco, IY Haddad, C Myles, JW Skimming, S Schurch, S Cheng, and S Cassin. Inhaled nitric oxide injures the pulmonary surfactant system in vivo. Am J Physiol 270 (Lung Cell Mol Physiol 14): L273-L280, 1996.
  10. Haddad IY, EJ Sorscher, RI Garver Jr., J Hong, E Tzeng, and S Matalon. Modulation of adenovirus-mediated gene transfer by nitric oxide. Am J Respir Cell Mol Biol. 1997 May 1; 16(5): 501-509.
  11. Zhu S, IY Haddad, and S Matalon. Modification of SP-A mannose-binding properties by reactive oxygen and nitrogen species. Arch Biochem Biophys 333(1): 282-290, 1996.
  12. Haddad IY, B Nievens-Cruz, P Hu, and S Matalon. Inhibition of the biophysical properties of surfactant mixtures by the co-administration of CuZn superoxide dismutase. J Appl Physiol. 1997 Nov 1; 83(5): 1545-1550.
  13. Jilling T, Haddad IY, SH Cheng, and S Matalon. Nitric oxide inhibits heterologous CFTR expression. Am J Physiol 277 (Lung Cell Mol Physiol 1):L89-L96, 1999.
  14. Haddad IY, DH Ingbar, A Panoskaltsis-Mortari, and BR Blazar. Allogeneic T cells activate alveolar macrophages to produce autotoxic levels of nitric oxide during bone marrow transplantation. Chest 116: 37S, 1999.
  15. Ingbar DH, R Bair, P Jung, J Heinecke, and IY Haddad. Hyperoxic lung injury increases HOCl-modified lung proteins. Chest 116: 100S, 1999.
  16. Haddad IY, A Panoskaltsis-Mortari, DH Ingbar, S Yang, C Milla, and BR Blazar. High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells: A potential mechanism of lung injury after marrow transplantation. Am J Resp Cell Mol Biol 20:1125-1135, 1999.
  17. Haddad IY, A Panoskaltsis-Mortari, DH Ingbar, ER Resnik, S Yang, CL Farrell, DL Lacey, DN Cornfield, and BR Blazar. Interactions of keratinocyte growth factor with a nitrating species after marrow transplantation in mice. Am J Physiol 277 (Lung Cell Mol Physiol 21): L391-L400, 1999.
  18. Panoskaltsis-Mortari A, DH Ingbar, P Jung, IY Haddad, PB Bitterman, OD Wangensteen, CL Farrell, DL Lacey, and BR Blazar. KGF pre-treatment decreases B7 and granzyme B expression and hastens repair in lungs of mice post-allogeneic bone marrow transplant. Am J Physiol (Lung Cell Mol Physiol 278): L988-L999, 2000.
  19. Yang S, A Panoskaltsis-Mortari, DH Ingbar, S Matalon, S Zhu, CL Farrell, DL Lacey, BR Blazar, and IY Haddad. Cyclophosphamide prevents systemic KGF-induced upregulation of SP-A after allogeneic transplantation in mice. Am J Resp Crit Care Med (accepted)
  20. Cornfield DN, CB Saqueton, VA Porter, J Herron, ER Resnik, IY Haddad, and HL Reeve. Voltage-gated K+ channel activity in the ovine pulmonary vasculature is developmentally regulated. Am J Physiol (Lung Cell Mol Physiol 278): L1297-L1305, 2000.

Inivited Manuscripts

  1. Matalon S, IY Haddad. Natural surfactant and hyperoxic lung injury in primates. J Appl Physiol, 76: 989-990, 1994.

Book Chapters

  1. Matalon S, S Zhu, Gy Pataki, and IY Haddad. Injury to pulmonary surfactant by reactive oxygen and nitrogen species. In: Correlations between in vitro and in vivo investigations in inhalation toxicology. Editors: D.L. Dungworth, K.B. Adler, C.C. Harris, and C.G. Plopper. ILSI Press pp. 230-251, 1997.
  2. Haddad IY, B Pitt, and S Matalon. Nitric oxide and lung injury. In: Pulmonary Diseases and Disorders, 3rd edition. Alfred P. Fishman, editor. Robert Senior, associate editor. McGraw-Hill pp. 337-346 (Chapter 26), 1998.
  3. Zhu S, M Manuel, IY Haddad, and S Matalon. Mechanisms of nitric oxide induced injury to the alveolar epithelium. S Matalon and JI Sznajder, editors. In: Acute respiratory distress syndrome. Cellular and molecular mechanisms and clinical management. NATO ASI series Vol 297, Plenum press, New York and London: pp. 345-354, 1998.
  4. Haddad IY, S Zhu, SJ Tilden, and S Matalon. Mechanisms and physiologic sequelae of reactive species injury to the alveolar epithelium. In: Lung Biology in Health and Disease. Chronic Lung Diseases of Early Infancy. Executive editor: Claude Lenfant; Section Editors: R. Bland and J. Coalson. New York, Marcel Dekker, Inc. Chapter 20, pp. 431-455, 1999.

Abstracts

  1. Haddad IY, ML Snelling, GB Smith, and TP Green. Assessment of alveolar edema and ion transport by bronchoalveolar lavage during oleic acid injury. Oral presentation at the Society of Critical Care Medicine Symposium, May 1991, and at the Fifth Pediatric Critical Care Colloquium, January, 1992.
  2. Snelling ML, IY Haddad, GB Smith, and TP Green. Amiloride and acidosis inhibit airway epithelial potential in newborn lambs. Oral presentation at the Fifth Pediatric Critical Care Colloquium, January, 1992.
  3. Holm BA, LM Halvaty, IY Haddad, and S. Matalon, Increased pH decreases the ability of CLSE to restore lung mechanics in surfactant-deficient lungs. Am Rev Resp Dis 147(4): 930, 1993. (Presented).
  4. Haddad IY, KT Goldsmith, RI Garver, and S. Matalon. Inhibition of surfactant protein A function by reactive nitrogen species. Am Rev Resp Dis, 147(4); 1985, 1993. (Presented).
  5. Matalon S. H Ischiropoulos, IY Haddad, BA Holm and J. Beckman. Peroxynitrite inhibition of surface activity of surfactant mixtures. Am Rev Resp Dis, 147(4)930, 1993. (Presented).
  6. Haddad IY, JS Beckman, R Garver, and S Matalon. Peroxynitrite injury to surfactant protein A (SP-A). Free Rad Biol Med 15(5): Abstract 4-30, 1993. (Presented).
  7. Haddad IY, P HU, Y Ye, CA Galliani, JS Beckman, and S. Matalon. Detection of nitrotyrosine in patients with Adult Respiratory Distress Syndrome (ARDS). FASEB J, 8(5): A 896, 1994. (Presented).
  8. Haddad IY, JP Crow, Y Ye, JS Beckman, and S. Matalon. Concurrent generation of nitric oxide and superoxide damages surfactant protein A (SP-A). Am J Resp Crit Care Med 149(4): A 549, 1994. (Presented).
  9. Haddad IY, E Barefield, C Wilson, J Cifuentes, S Zu, P Hu, and S Matalon. Effects of nitric oxide on alveolar type II cell ATP and lipid synthesis. Am J Resp Crit Care Med 151(4): A 647, 1995. (Presented).
  10. Haddad IY, P Hu, and S Matalon. Increased production of nitric oxide during exposure of rats to hyperoxia in vivo. Am J Resp Crit Care Med 151(4): A 647, 1995. (Presented).
  11. Haddad IY, Z Bebok, J Hong, E Sorscher, and S Matalon. Induction and toxicity of nitric oxide-derived species during adenovirus-mediated gene transfer. Pediatric Pulmonology (12): A 342, September 1995. (Presented).
  12. Haddad IY, R Garver Jr., EJ Sorscher, E Tzeng, and S Matalon. Decreased efficiency of adenovirus-mediated gene transfer by nitric oxide. Am J Resp Crit Care Med 153(4): A110, 1996. (Presented).
  13. Zhu S, IY Haddad, and S Matalon. Nitration of surfactant protein A (SP-A) results in decreased mannose-binding ability. Am J Resp Crit Care Med 153(4): A103, 1996. (Presented).
  14. Haddad IY, EJ Sorscher, RI Garver Jr., and S Matalon. Mechanisms of nitric oxide-mediated suppression of gene transfer in vitro. Pediatric Pulmonology (13): A170, september, 1996. (Presented)
  15. Jilling T, IY Haddad, EJ Sorscher, KL Kirk, and S Matalon. Exogenous nitric oxide inhibits the heterologous expression of CFTR in LLCPK1 cells. Pediatric Pulmonology (13): A69, september, 1996. (Presented) .
  16. Haddad IY, and S Matalon. The role of free radicals during adenovirus-mediated gene transfer. Am J Resp Crit Care Med. Am J Resp Crit Care Med 155(4): A194, 1997. (Presented).
  17. Jilling T, IY Haddad, EJ Sorscher, SH Cheng, and S Matalon. Nitric oxide-dependent inhibition of heterologous CFTR expression. Pediatric Pulmonology (14): A407, August 1997. (Presented)
  18. Haddad IY, T Jilling, and S Matalon. Effects of nitric oxide on transgene expression in transduced epithelial and fibroblast cell lines. The second International Meeting on Oxygen/Nitrogen Radicals and Cellular Injury; Durham, North Carolina, September, 1997. (Presented).
  19. Haddad IY, A Ponaskaltis-Mortari, D Ingbar, C Milla, and B Blazar. Allogeneic T cells activate alveolar macrophages to produce autotoxic levels of nitric oxide during bone marrow transplantation (BMT). Am J Resp Crit Care Med 157(3): A272, 1998. (Presented).
  20. Haddad IY, A Panoskaltsis-Mortari, DH Ingbar, ER Resnik, S Yang, and BR Blazar. The pre-transplantation administration of keratinocyte growth factor (KGF) prevents the development of idiopathic pneumonia syndrome. Am J Resp Crit Care Med 159(3):A605, 1999. (Poster presentation; American Thoracic Society).
  21. Panoskaltsis-Mortari, A, IY Haddad., DH Ingbar, PB Bitterman, D Wangensteen, DL Lacey, and BR Blazar. Keratinocyte growth factor (KGF) induces Th2 cytokines and attenuates early inflammatory mediator expression in the lung following allogeneic BMT in mice. Faseb J 13(5):A485.7, 1999. (Poster presentation; American Physiological Society).
  22. Haddad IY, S Yang, A Panoskaltsis-Mortari, DH Ingbar, and BR Blazar. Systemic keratinocyte growth factor upregulates the production of surfactant protein A after allogeneic marrow transplantation. Am J Resp Crit Care Med 160(3):A44, 2000. (Poster presentation; American Thoracic Society)
  23. Yang S, A. Panoskaltsis-Mortari, S Matalon, B.R. Blazar, and IY Haddad. In vivo injection of human SP-A suppresses T cell-dependent activation of macrophages/monocytes in a murine model of lung injury after bone marrow transplantation. 2000 FASEB Summer Research Conferences.

Major Lectures and Visiting Professorship

Invited Lectures at Local Meetings

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This page last updated June 9, 2000 at 1125 CDT